Alpha-lipoic acid did not affect lipid profile and blood pressure in critically ill patients: A randomized, double-blind clinical trial-Reference-Cited by-同舟云学术

Alpha-lipoic acid did not affect lipid profile and blood pressure in critically ill patients: A randomized, double-blind clinical trial

Published:2021-12-07 Issue: Volume: Page:1-9
ISSN:1973-798X
Container-title:Mediterranean Journal of Nutrition and Metabolism
language:
Short-container-title:MNM

Author:

Mohamadi Azam¹,Moravejolahkami Amir Reza²^ORCID,Askari Gholamreza³,Tarrahi Mohammad Javad⁴,Hajiesmaeili Mohammadreza⁵,Bahreini-Esfahani Nimah⁶^ORCID

Affiliation:

1. M. Sc. of Nutrition, Department of Community Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

2. Ph.D.Candidate of Nutrition, Department of Clinical Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

3. Associate Prof. of Nutrition, Department of Community Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

4. Associate Prof. of Epidemiology, Department ofEpidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

5. Assistant Prof. of Anesthesiology & Critical Care, Anesthesiology Research Center, Anesthesia and Critical Care Department, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

6. Assistant Prof. of Nutrition, Department of Community Nutrition, School of Nutrition & Food Science, IsfahanUniversity of Medical Sciences, Isfahan, Iran

Abstract

BACKGROUND: Some researchers suggested a positive effect of Alpha-Lipoic Acid (ALA) on Blood Pressure (BP) and lipid profile. OBJECTIVE: The aim of this study was to determine the efficacy of ALA for improving BP and lipid profile in critically ill patients. METHODS: In the present study, eighty patients (aged 18–80 years old) were randomly assigned to receive daily either ALA (600 mg/day) or placebo for eight weeks. Systolic BP (SBP), Diastolic BP (DBP), Triglyceride (TG), Total cholesterol (TC), Low Density Lipoprotein (LDL), and High Density Lipoprotein (HDL) were measured before and after intervention. RESULTS: LDL decreased significantly in the ALA group (110.6±34.9 vs. 107.9±33.4 mg/dl; P < 0.05). There was also a significant difference in terms of HDL in both groups (Δ= +1.8 vs. Δ= –0.3 mg/dl; P < 0.05). A marginal non-significant reduction was also observed for SBP. There were no significant differences in other variables between the two groups. CONCLUSIONS: ALA supplementation did not improve the BP and some serum lipid markers in critically ill patients. Larger and longer trials will be needed to determine efficacy of ALA.

Publisher

IOS Press

Subject

Nutrition and Dietetics,Food Science,Endocrinology, Diabetes and Metabolism

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