NEURONORMA Cognitive Battery Associations with Cerebrospinal Fluid Amyloid-β and Tau Levels in the Continuum of Alzheimer’s Disease

Author:

García-Escobar Greta1,Puig-Pijoan Albert12,Puente-Periz Víctor12,Fernández-Lebrero Aida123,María Manero Rosa12,Navalpotro-Gómez Irene123,Suárez-Calvet Marc2345,Grau-Rivera Oriol2345,Contador-Muñana José123,Cascales-Lahoz Diego2,Duran-Jordà Xavier4,Boltes Núncia6,Pont-Sunyer Maria Claustre6,Ortiz-Gil Jordi678,Carrillo-Molina Sara67,López-Villegas María Dolores49,Abellán-Vidal María Teresa9,Martínez-Casamitjana María Isabel9,Hernández-Sánchez Juan José10,Padrós-Fluvià Anna10,Peña-Casanova Jordi1,Sánchez-Benavides Gonzalo345

Affiliation:

1. Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain

2. Cognitive Impairment and Movement Disorders Unit, Neurology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain

3. Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain

4. IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain

5. Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain

6. Neurology Department, Hospital General de Granollers, Granollers, Spain

7. Psychology Unit, Hospital General de Granollers, Granollers, Spain

8. Maria Angustias Gimenez Research Foundation (FIDMAG), Sant Boi del Llobregat, Spain

9. Centre Emili Mira, Institut de Neuropsiquiatria i Addiccions (INAD), Parc de Salut Mar, Santa Coloma de Gramenet, Spain

10. Laboratori de Referència de Catalunya, Sant Boi del Llobregat, Spain

Abstract

Background: Neuropsychological assessments are essential to define the cognitive profile and contribute to the diagnosis of Alzheimer’s disease (AD). The progress in knowledge about the pathophysiological process of the disease has allowed conceptualizing AD through biomarkers as a biological continuum that encompasses different clinical stages. Objective: To explore the association between cerebrospinal fluid (CSF) biomarkers of AD and cognition using the NEURONORMA battery, in a sample of cognitively unimpaired (CU), mild cognitive impaired (MCI), and mild dementia of the Alzheimer type (DAT) subjects, and to characterize the cognitive profiles in MCI subjects classified by A/T/N system. Methods: 42 CU, 35 MCI, and 35 mild DAT were assessed using the NEURONORMA battery. Core AD biomarkers [amyloid-β42 (Aβ42) peptide, total tau (t-tau), and phosphorylated tau 181 (p-tau181)] proteins were measured in CSF. Correlation coefficients, multivariate regression, and effect sizes were calculated. We explored the age- and education-adjusted cognitive profiles by A/T/N variants within the MCI group. Results: Cognitive outcomes were directly associated with CSF Aβ42 and inversely with CSF tau measures. We found differences in both biomarkers and cognitive outcomes comparing all pairs except for CSF measures between cognitively impaired groups. The highest effect size was in memory tasks and biomarkers ratios. Lower performances were in memory and executive domains in MCI subjects with AD pathology (A+T+N±) compared to those with normal levels of AD biomarkers (A– T– N). Conclusion: This study provides further evidence of the validity of Spanish NEURONORMA cognitive battery to characterize cognitive impairment in the AD pathological continuum.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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