Pharmacokinetics in Rat of P8, a Peptide Drug Candidate for the Treatment of Alzheimer’s Disease: Stability and Delivery to the Brain1-Reference-Cited by-同舟云学术

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Pharmacokinetics in Rat of P8, a Peptide Drug Candidate for the Treatment of Alzheimer’s Disease: Stability and Delivery to the Brain1

Published:2018-10-24 Issue:1 Volume:2 Page:169-179
ISSN:2542-4823
Container-title:Journal of Alzheimer's Disease Reports
language:
Short-container-title:ADR

Author:

Dewji Nazneen N.¹²,Azar Marc R.³,Hanson Leah R.⁴,Frey II William H.⁴,Morimoto Bruce H.⁵,Johnson David⁶

Affiliation:

1. Cenna Biosciences Inc., La Jolla, CA, USA

2. Department of Medicine, UC San Diego, La Jolla, CA, USA

3. Behavioral Pharma, La Jolla, CA, USA

4. HealthPartners Institute, St. Paul, MN, USA

5. Celerion Inc., USA

6. Microconstants LLC, San Diego, CA, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Neuroscience

Reference21 articles.

1. The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics;Hardy;Science,2002

2. Insights into the physiological function of the P-amyloid precursor protein: Beyond Alzheimer’s disease;Dawkins;J Neurochem,2014

3. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer’s disease;Oddo;Neurobiol Aging,2003

4. Neurotoxic amyloid beta oligomeric assemblies recreated in microfluidic platform with interstitial level of slow flow;Choi;Sci Rep,2013

5. The role of presenilin cofactors in the gamma-secretase complex;Takasugi;Nature,2003

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1. AmyP53, a Therapeutic Peptide Candidate for the Treatment of Alzheimer’s and Parkinson’s Disease: Safety, Stability, Pharmacokinetics Parameters and Nose-to Brain Delivery;International Journal of Molecular Sciences;2022-11-02

2. Effect of Cerebrospinal Fluid Circulation on Nose-to-Brain Direct Delivery and Distribution of Caffeine in Rats;Molecular Pharmaceutics;2020-09-21

3. Preformulation Studies of a Stable PTEN-PDZ Lipopeptide Able to Cross an In Vitro Blood-Brain-Barrier Model as a Potential Therapy for Alzheimer’s Disease;Pharmaceutical Research;2020-09-04

4. IgG Fc-binding motif-conjugated HIV-1 fusion inhibitor exhibits improved potency and in vivo half-life: Potential application in combination with broad neutralizing antibodies;PLOS Pathogens;2019-12-05

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