Recent Advances on Possible Association Between the Periodontal Infection of Porphyromonas gingivalis and Central Nervous System Injury

Author:

Yu Wenlei12,Lu Linjie12,Ji Xintong12,Qian Qiwei12,Lin Xiaohan1,Wang Huanhuan12

Affiliation:

1. School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China

2. Laboratory of Aging and Cancer Biology of Zhejiang Province, Hangzhou Normal University, Hangzhou, China

Abstract

Chronic periodontitis caused by Porphyromonas gingivalis (P. gingivalis) infection generally lasts for a lifetime. The long-term existence and development of P. gingivalis infection gradually aggravate the accumulation of inflammatory signals and toxic substances in the body. Recent evidence has revealed that P. gingivalis infection may be relevant to some central nervous system (CNS) diseases. The current work collects information and tries to explore the possible relationship between P. gingivalis infection and CNS diseases, including the interaction or pathways between peripheral infection and CNS injury, and the underlying neurotoxic mechanisms.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Acupuncture for Counteracting P2X4 and P2X7 Receptor Involvement in Neuroinflammation;Purinergic Signaling in Neurodevelopment, Neuroinflammation and Neurodegeneration;2023

2. Impact of New Drugs for Therapeutic Intervention in Alzheimer’s Disease;Frontiers in Bioscience-Landmark;2022-05-06

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