Selective detection of superoxide by benzoselenadiazole based BODIPY probe: Synthesis and biological activity-Reference-Cited by-同舟云学术

Selective detection of superoxide by benzoselenadiazole based BODIPY probe: Synthesis and biological activity

Published:2024-04-25 Issue: Volume: Page:1-10
ISSN:1024-1221
Container-title:Main Group Chemistry
language:
Short-container-title:MGC

Author:

Deshmukh Pratiksha P.¹,Shelar Divyesh S.¹²,Dhavan Pratik P.²,Jadhav Bhaskar L.³,Manjare Sudesh T.³

Affiliation:

1. Department of Chemistry, University of Mumbai, Mumbai, India

2. Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany

3. Department of Life science, University of Mumbai, Mumbai, India

Abstract

New benzoselenadiazole based BODIPY probe was synthesized and characterized with spectroscopic techniques like 1H, 13C, 77Se and mass spectrometry. The fluorescence of the probe quenched in the presence of superoxide ion, showing “Turn-off” response without interfering with other ROS even at higher concentrations. The detection limit was found to be 21.28μM. Kinetic study reveal the fast reaction between the probe and superoxide with good photostability. Also, the probe was studied for biological activity and found to be good agent for anti-inflammatory and antioxidant activities.

Publisher

IOS Press

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