Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling

Author:

Chen Ci-Di1,Zeldich Ella1,Khodr Christina1,Camara Kaddy23,Tung Tze Yu4,Lauder Emma C.5,Mullen Patrick1,Polanco Taryn J.1,Liu Yen-Yu4,Zeldich Dean6,Xia Weiming78,Van Nostrand William E.9,Brown Lauren E.237,Porco John A.23,Abraham Carmela R.17

Affiliation:

1. Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA

2. Department of Chemistry, Boston University, Boston, MA, USA

3. Center for Molecular Discovery (BU-CMD), Boston University, Boston, MA, USA

4. Department of Biology, Boston University, Boston, MA, USA

5. Department of Neuroscience, Boston University, Boston, MA, USA

6. Department of Biomedical Engineering, Boston University, Boston, MA, USA

7. Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA

8. Bedford Geriatric Research Education Clinical Center, Bedford VA Medical Center, Bedford, MA, USA

9. Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference53 articles.

1. The amyloid hypothesis of Alzheimer’s disease at 25 years;Selkoe;EMBO Mol Med,2016

2. Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-βeta precursor protein dimerization;So;Am J Neurodegener Dis,2012

3. APP processing is regulated by cytoplasmic phosphorylation;Lee;J Cell Biol,2003

4. ELISA analysis of beta-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways;Steinhilb;J Neurochem,2002

5. Phosphorylation of amyloid precursor protein (APP) at Tyr687 regulates APP processing by alpha- and gamma-secretase;Takahashi;Biochem Biophys Res Commun,2008

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