Cognitive Variability Predicts Incident Alzheimer’s Disease and Mild Cognitive Impairment Comparable to a Cerebrospinal Fluid Biomarker

Author:

Gleason Carey E.123,Norton Derek34,Anderson Eric D.5,Wahoske Michelle13,Washington Danielle T.123,Umucu Emre6,Koscik Rebecca L.7,Dowling N. Maritza8,Johnson Sterling C.1238,Carlsson Cynthia M.1238,Asthana Sanjay1238,

Affiliation:

1. Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

2. Geriatric Research, Education and Clinical Center (11G), William S. Middleton Memorial Veterans Hospital, Madison, WI, USA

3. Wisconsin Alzheimer’s Disease Research Center, Madison, WI, USA

4. University of Wisconsin, Department of Biostatistics and Medical Informatics, Madison, WI, USA

5. Wright State University, School of Education and Human Services, Dayton, OH, USA

6. Department of Rehabilitation Sciences, University of Texas at El Paso, El Paso, TX, USA

7. Wisconsin Alzheimer’s Institute, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

8. George Washington University, School of Nursing, Washington, DC, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference37 articles.

1. Tracking pathophysiological processes in Alzheimer’s disease: An updated hypothetical model of dynamic biomarkers;Jack;Lancet Neurol,2013

2. CSF and blood biomarkers for the diagnosis of Alzheimer’s disease: A systematic review and meta-analysis;Olsson;Lancet Neurol,2016

3. CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings;Seppala;Neurology,2012

4. Correlation of longitudinal cerebrospinal fluid biomarkers with cognitive decline in healthy older adults;Stomrud;Arch Neurol,2010

5. Fletcher LC , Burke KE , Caine PL , Rinne NL , Braniff CA , Davis HR , Miles KA , Packer C (2013) Diagnosing Alzheimer’s disease: Are we any nearer to useful biomarker-based, non-invasive tests? GMS Health Technol Assess 9, Doc01.

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