1. Department of Radiology, University of North Carolina-Chapel Hill, UNC-Lineberger Comprehensive Cancer Center, CB #7510, Chapel Hill, NC 27599-7510, USA. E-mail: etpisano@med.unc.edu
2. Departments of Medical Biophysics and Medical Imaging, Medical Imaging Research Group, University of Toronto, Sunnybrook Health Science Centre, Toronto, Ontario, Canada M5S 1A8