Effects of L-arginine on impaired blood fluidity after high-intensity exercise: An in vitro evaluation

Author:

Namba Haruchi1,Hamada Hironobu1,Kimura Tatsushi2,Sekikawa Kiyokazu1,Kamikawa Norimichi3,Ishio-Ueoka Hatsumi1,Kajiwara Teruki1,Sato Yoshinobu M.1,Aizawa Fumiya1,Yoshida Takamasa1

Affiliation:

1. Department of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

2. Faculty of Early Childhood Education and Care, Ohkagakuen University, Aichi, Japan

3. Department of Rehabilitation, Faculty of Health Sciences, Hiroshima Cosmopolitan University, Hiroshima, Japan

Abstract

BACKGROUND: Exercise-induced impairment of blood fluidity is considered to be associated with thrombosis development. However, the effects of L-arginine on blood fluidity after exercise remain unclear. OBJECTIVE: We investigated the mechanisms of impaired blood fluidity after high-intensity exercise, and examined whether L-arginine improves exercise-induced blood fluidity impairment in vitro. METHODS: Ten healthy male participants performed 15 minutes of ergometer exercise at 70% of their peak oxygen uptake levels. Blood samples were obtained before and after exercise. L-arginine and NG-monomethyl-L-arginine acetate (L-NMMA)—a nitric oxide (NO) synthase inhibitor—were added to the post-exercise blood samples. Using Kikuchi’s microchannel method, we measured the blood passage time, percentage of obstructed microchannels, and the number of adherent white blood cells (WBCs) on the microchannel terrace. RESULTS: Exercise increased the hematocrit levels. The blood passage times, percentage of obstructed microchannels, and the number of adherent WBCs on the microchannel terrace increased after exercise; however, they decreased in a dose-dependent manner after the addition of L-arginine. L-NMMA inhibited the L-arginine-induced decrease in blood passage time. CONCLUSIONS: High-intensity exercise impairs blood fluidity by inducing hemoconcentration along with increasing platelet aggregation and WBC adhesion. The L-arginine–NO pathway improves blood fluidity impairment after high-intensity exercise in vitro.

Publisher

IOS Press

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Hematology,Physiology

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