Similar Progression of Morphological and Metabolic Phenotype in R6/2 Mice with Different CAG Repeats Revealed by In Vivo Magnetic Resonance Imaging and Spectroscopy

Author:

Sawiak Stephen J.12,Wood Nigel I.3,Morton A. Jennifer3

Affiliation:

1. Wolfson Brain Imaging Centre, University of Cambridge, Box 65 Addenbrooke’s Hospital, Cambridge, UK

2. Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK

3. Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

Publisher

IOS Press

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

Reference55 articles.

1. Huntington’s disease;Walker;Lancet,2007

2. Huntingtin localization in brains of normal and Huntington’s disease patients;Sapp;Ann Neurol,1997

3. Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington’s disease mutation;Morton;J Neurocytol,2000

4. Mouse models of Huntington’s disease;Menalled;Trends Pharmacol Sci,2002

5. Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats;Rubinsztein;Am J Hum Genet,1996

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