The effect of T helper (Th)/T cytotoxic (Tc) ratio on disease severity in type A hemophilia patients-Reference-Cited by-同舟云学术

The effect of T helper (Th)/T cytotoxic (Tc) ratio on disease severity in type A hemophilia patients

Published:2021-03-24 Issue:1 Volume:29 Page:95-99
ISSN:1875-869X
Container-title:Human Antibodies
language:
Short-container-title:HAB

Author:

Khazaei Hossein Ali¹,Naderi Majid²,Aliabad Ghasem Miri³,Tabatabaei Seyed Mohammad Nasiraldin¹,Alidadi Ali¹,Moulaei Nezar Ali⁴,Safdari Mohammad¹,Nahvi Hedayatollah⁵,Cohan Nader⁶,Dehghan Javid⁷,Mehraban Ahmad⁸,Jalili Arman⁹,Khazaei Amin¹,Khazaei Ehsan¹,Khazaei Bahman¹,Khazaei Behnam¹,Rezaei Nima¹⁰,Salarzaie Morteza¹¹,Soleimani Gholamreza³

Affiliation:

1. Clinical Immunology Research Center (CIRC), Zahedan University of Medical Sciences, Zahedan, Iran

2. Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

3. Children and Adolescents Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

4. Infectious Disease and Tropical Medicine Research Center, Resistance Tuberculosis Institute of Zahedan University of Medical Sciences, Zahedan, Iran

5. Department of Pediatric Surgery, Tehran University of Medical Sciences, Tehran, Iran

6. Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

7. Community Medicine Department, Zahedan University of Medical Sciences, Zahedan, Iran

8. Islamic Azad University, Zahedan Branch, Zahedan, Iran

9. Department of Sport Physiology, Zahedan University of Farhangian, Zahedan, Iran

10. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

11. Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran

Abstract

BACKGROUND AND OBJECTIVES: The aim of this study was to investigate the T helper (Th) to T cytotoxic (Tc) ratio in children suffering from type A hemophilia disease and to evaluate the correlation of this ratio with disease severity. MATERIAL AND METHOD: Two mls of EDTA anti coagulated whole blood was collected. Immunophenotyping of lymphocytes count was carried out by FACS analysis using a double CD4 and CD8 kit. The mean ± SD of absolute numbers of CD4 and CD8 lymphocytes/ml was calculated and the ratio of CD4/CD8 was evaluated by statistical method. RESULTS: Among 80 type A hemophilia patients, 66 (82.5%) were male. The mean age was 15 ± 3.51 years. 12 (15%) of them were suffering from mild disease and 68 (85%) had sever disease. The CD4 /CD8 ratio was obtained between 0.45 and 1.44 with mean1.79 ± 0.78. The correlation between this ration and disease severity was 0.019. CONCLUSION: The results showed that CD4/CD8 ratio has correlation with disease severity in type A hemophilia patients, however there was no association between this ratio and gender.

Publisher

IOS Press

Subject

General Medicine,Immunology,Immunology and Allergy

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