Expression Profiling of Rectal Biopsies Suggests Altered Enteric Neuropathological Traits in Parkinson’s Disease Patients-Reference-Cited by-同舟云学术

Expression Profiling of Rectal Biopsies Suggests Altered Enteric Neuropathological Traits in Parkinson’s Disease Patients

Published:2021-02-02 Issue:1 Volume:11 Page:171-176
ISSN:1877-7171
Container-title:Journal of Parkinson's Disease
language:
Short-container-title:JPD

Author:

Cossais François¹,Schaeffer Eva²,Heinzel Sebastian²,Zimmermann Jessica¹,Niesler Beate³⁴⁵,Röth Ralph³⁴,Rappold Gudrun³⁴⁵,Scharf Amelie¹,Zorenkov Dmitri²,Lange Christina¹,Barrenschee Martina¹,Margraf Nils G.²,Ellrichmann Mark⁶,Berg Daniela²,Böttner Martina¹,Wedel Thilo¹

Affiliation:

1. Institute of Anatomy, Christian-Albrechts-University of Kiel, Kiel, Germany

2. Department of Neurology, University Hospital Schleswig-Holstein, Christian-Albrechts-University of Kiel, Kiel, Germany

3. Department of Human Molecular Genetics, Institute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany

4. nCounter Core Facility, Institute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany

5. Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany

6. Interdisciplinary Endoscopy, Medical Department I, University Hospital Schleswig-Holstein, Christian-Albrechts-University of Kiel, Kiel, Germany

Abstract

Still little is known about the nature of the gastrointestinal pathological alterations occurring in Parkinson’s disease (PD). Here, we used multiplexed mRNA profiling to measure the expression of a panel of 770 genes related to neuropathological processes in deep submucosal rectal biopsies of PD patients and healthy controls. Altered enteric neuropathological traits based on the expression of 22 genes related to neuroglial and mitochondrial functions, vesicle trafficking and inflammation was observed in 9 out of 12 PD patients in comparison to healthy controls. These results provide new evidences that intestinal neuropathological alterations may occur in a large proportion of PD patients.

Publisher

IOS Press

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

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