Latrepirdine (Dimebon™) Enhances Autophagy and Reduces Intracellular GFP-Aβ42 Levels in Yeast

Author:

Bharadwaj Prashant R.12,Verdile Giuseppe134,Barr Renae K.1,Gupta Veer1,Steele John W.56,Lachenmayer M. Lenard57,Yue Zhenyu58,Ehrlich Michelle E.5910,Petsko Gregory11,Ju Shulin11,Ringe Dagmar11,Sankovich Sonia E.2,Caine Joanne M.2,Macreadie Ian G.212,Gandy Sam5613,Martins Ralph N.134

Affiliation:

1. Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, WA, Australia

2. CSIRO Preventative Health Flagship, Material Science and Engineering, VIC, Australia

3. School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia

4. Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Nedlands, WA, Australia

5. Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA

6. Department of Psychiatry and Alzheimer's Disease Research Centre, Mount Sinai School of Medicine, New York, NY, USA

7. Department of Neurology, University of Bonn, Bonn, Germany

8. Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA

9. Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA

10. Department of Paediatrics, Mount Sinai School of Medicine, New York, NY, USA

11. Department of Biochemistry and Chemistry, Rosenstiel Basic Medical Sciences Research Centre, Brandeis University, Waltham, MA, USA

12. School of Applied Sciences, RMIT University, Bundoora West Campus, Bundoora, VIC, Australia

13. James J Peters VA Medical Centre, Bronx, NY, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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