A 19-Year-Old Adolescent with Probable Alzheimer’s Disease1-Reference-Cited by-同舟云学术

A 19-Year-Old Adolescent with Probable Alzheimer’s Disease1

Published:2023-01-31 Issue:3 Volume:91 Page:915-922
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Jia Jianping¹²³⁴⁵,Zhang Yue¹,Shi Yuqing¹,Yin Xuping¹,Wang Shiyuan¹,Li Yan¹,Zhao Tan¹,Liu Wenying¹,Zhou Aihong¹,Jia Longfei¹

Affiliation:

1. Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, P.R. China

2. Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, P.R. China

3. Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, P.R. China

4. Center of Alzheimer’s Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, P.R. China

5. Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, P.R. China

Abstract

Alzheimer’s disease (AD) primarily affects older adults. In this report, we present the case of a 19-year-old male with gradual memory decline for 2 years and World Health Organization-University of California Los Angeles Auditory Verbal Learning Test (WHO-UCLA AVLT) results also showing memory impairment. Positron emission tomography-magnetic resonance imaging with 18F fluorodeoxyglucose revealed atrophy of the bilateral hippocampus and hypometabolism in the bilateral temporal lobe. Examination of the patient’s cerebrospinal fluid showed an increased concentration of p-tau181 and a decreased amyloid-β 42/40 ratio. However, through whole-genome sequencing, no known gene mutations were identified. Considering the above, the patient was diagnosed with probable AD.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference41 articles.

1. Gene mutations associated with early onset familial Alzheimer’s disease in China: An overview and current status;Qin;Mol Genet Genomic Med,2020

2. De novo PS1 mutation (Pro436Gln) in a very early-onset posterior variant of Alzheimer’s disease associated with spasticity: A case report;Aguero;J Alzheimers Dis,2021

3. Variability and heterogeneity in Alzheimer’s disease with cotton wool plaques: A clinicopathological study of four autopsy cases;Yokota;Acta Neuropathol,2003

4. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician;Folstein;J Psychiatr Res,1975

5. The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment;Nasreddine;J Am Geriatr Soc,2005

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Oleanonic acid ameliorates mutant Aβ precursor protein-induced oxidative stress, autophagy deficits, ferroptosis, mitochondrial damage, and ER stress in vitro;Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;2024-12

2. Current progress in aptamer-based sensors for the detection of protein biomarkers in neurodegenerative diseases;Biosensors and Bioelectronics: X;2024-10

3. Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition;Journal of Hazardous Materials;2024-09

4. From aberrant neurodevelopment to neurodegeneration: Insights into the hub gene associated with autism and alzheimer's disease;Brain Research;2024-09

5. Employing a Toxic Aging Coin approach to assess hexavalent chromium (Cr[VI])-induced neurotoxic effects on behavior: Heads for age differences;Toxicology and Applied Pharmacology;2024-08