Association of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease: New Entity or Coincidence? A Case Series-Reference-Cited by-同舟云学术

Association of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease: New Entity or Coincidence? A Case Series

Published:2021-12-07 Issue:4 Volume:84 Page:1439-1446
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Vrillon Agathe¹²,Deramecourt Vincent³,Pasquier Florence³,Magnin Éloi⁴,Wallon David⁵,Lozeron Pierre⁶,Bouaziz-Amar Élodie⁷²,Paquet Claire⁸²

Affiliation:

1. APHP GHU Nord Lariboisière Fernand-Widal, Cognitive Neurology Centre, Paris, France

2. Université de Paris Inserm UMR S1144 Optimization in Neuropsychopharmacology, Paris, France

3. Université de Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, CNRMAJ, LiCEND, DistAlz, Lille, France

4. Département de Neurologie, University Hospital of Besançon, Besançon, France; Clinical and Integrative Neuroscience, Research Laboratory 481, Bourgogne Franche-Comté University, Besançon, France

5. Normandie Univ, UNIROUEN, Inserm U1245, Rouen University Hospital, Department of Neurology and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, CIC-CRB1404, Rouen, France

6. Service de Physiologie Clinique-Explorations Fonctionnelles, APHP, Hôpital Lariboisière, Paris, France

7. Service de Biochimie et Biologie moléculaire, APHP GHU Nord Lariboisière-Fernand Widal, Paris, France

8. APHP GHU Nord Lariboisière Fernand-Widal, Centre de Neurologie Cognitive, Paris, France

Abstract

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia have a strong clinical, genetic, and pathological connection but association of ALS with Alzheimer’s disease (AD) is seldom reported. We report a series of 5 cases of AD associated with ALS. Our patients presented with cognitive deterioration with episodic memory impairment meeting criteria for AD. ALS occurred subsequently in all cases and its phenotype was not homogenous. Amyloid process was confirmed in four cases with cerebrospinal fluid biomarkers. One case underwent postmortem exam, demonstrating hallmarks lesions of both diseases. This series highlights that ALS-AD phenotype could be a specific underexplored entity.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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