CHRNA7 Gene and Response to Cholinesterase Inhibitors in an Italian Cohort of Alzheimer’s Disease Patients

Author:

Clarelli Ferdinando1,Mascia Elisabetta1,Santangelo Roberto2,Mazzeo Salvatore2,Giacalone Giacomo2,Galimberti Daniela3,Fusco Federica4,Zuffi Marta5,Fenoglio Chiara3,Franceschi Massimo5,Scarpini Elio3,Forloni Gianluigi4,Magnani Giuseppe2,Comi Giancarlo12,Albani Diego4,Martinelli Boneschi Filippo12

Affiliation:

1. Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy

2. Department of Neurology, San Raffaele Hospital, Milan, Italy

3. Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cá Granda, IRCCS Ospedale Policlinico, Milan, Italy

4. IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri” via La Masa, Milan, Italy

5. Department of Neurology, Multimedica Hospital Castellanza (Va), Castellanza, Italy

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference17 articles.

1. Alpha7 nicotinic acetylcholine receptor gene and reduced risk of Alzheimer’s disease;Carson;J Med Genet,2008

2. APOE, ACT and CHRNA7 genes in the conversion from amnestic mild cognitive impairment to Alzheimer’s disease;Barabash;Neurobiol Aging,2009

3. CHRNA7 polymorphisms and response to cholinesterase inhibitors in Alzheimer’s disease;Weng;PloS One,2013

4. Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer’s disease;Braga;Am J Alzheimers Dis Other Demen,2015

5. Russo P , Kisialiou A , Moroni R , Prinzi G , Fini M (2015) Effect of genetic polymorphisms (SNPs) in CHRNA7 gene on response to acetylcholinesterase inhibitors (AChEI) in patients with Alzheimer’s disease. Curr Drug Targets 16, (E-pub ahead of print)

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