Genetic Variation in δ-Opioid Receptor Associates with Increased β- and γ-Secretase Activity in the Late Stages of Alzheimer’s Disease

Author:

Sarajärvi Timo12,Marttinen Mikael12,Natunen Teemu12,Kauppinen Tarja2,Mäkinen Petra12,Helisalmi Seppo2,Laitinen Marjo23,Rauramaa Tuomas45,Leinonen Ville6,Petäjä-Repo Ulla7,Soininen Hilkka23,Haapasalo Annakaisa28,Hiltunen Mikko123

Affiliation:

1. Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

2. Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland

3. Department of Neurology, Kuopio University Hospital, Kuopio, Finland

4. Department of Pathology, Kuopio University Hospital, Kuopio, Finland

5. Institute of Clinical Medicine – Pathology, University of Eastern Finland, Kuopio, Finland

6. Institute of Clinical Medicine – Neurosurgery, University of Eastern Finland and Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland

7. Medical Research Center Oulu and Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland

8. Department of Neurobiology, A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference24 articles.

1. Alzheimer’s disease: Genes, proteins, and therapy;Selkoe;Physiol Rev,2001

2. Mechanisms of tau-induced neurodegeneration;Iqbal;Acta Neuropathol,2009

3. Proteolytic processing and cell biological functions of the amyloid precursor protein;De Strooper;J Cell Sci,2000

4. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model;Postina;J Clin Invest,2004

5. Take five–BACE and the gamma-secretase quartet conduct Alzheimer’s amyloid beta-peptide generation;Haass;EMBO J,2004

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