Relationship between serum zinc, HOMA2 parameters and glycemic status in a regional Australian hospital population

Abstract

BACKGROUND: Previous studies demonstrated lower serum zinc among prediabetics and diabetics, compared to normoglycemics, however no current data is available for regional Australia. OBJECTIVE: We aimed to determine the relationship between serum zinc, glycemic status and Homeostasis Model Assessment (HOMA2) parameters in a regional Australian hospital population. METHODS: Retrospective review of patients presenting to a regional Australian hospital between June-2004 and April-2017 was conducted. Patients ordered for fasting blood glucose (FBG)+serum zinc; or FBG+serum insulin; or FBG+serum zinc+serum insulin were included. Serum zinc, FBG, serum insulin, lipid profile, vitamin-D and demographic information were collected. β-cell function, insulin resistance and insulin sensitivity were calculated by HOMA2 calculator. RESULTS: Three hundred and thirteen patient records were retrieved: 75% normoglycemic, 19% prediabetic, 6% diabetic. Serum zinc was lowest in diabetics and lower in prediabetics than normoglycemics. In simple linear regression among all participants, higher serum zinc associated with increased insulin sensitivity, decreased insulin resistance and decreased β-cell function. CONCLUSIONS: The low serum zinc status exhibited in diabetic and prediabetic individuals may play a role in insulin resistance pathogenesis. Higher zinc levels associated with greater insulin sensitivity and lower insulin resistance signifying the importance of investigating zinc supplementation in prediabetics to prevent or delay diabetes in future studies.