Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents

Author:

Polinski Nicole K.1,Volpicelli-Daley Laura A.2,Sortwell Caryl E.3,Luk Kelvin C.4,Cremades Nunilo5,Gottler Lindsey M.6,Froula Jessica2,Duffy Megan F.3,Lee Virginia M.Y.4,Martinez Terina N.1,Dave Kuldip D.1

Affiliation:

1. The Michael J. Fox Foundation for Parkinson’s Research, New York, NY, USA

2. Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA

3. Department of Translational Science and Molecular Medicine, Michigan State University, Grand Rapids, MI, USA

4. Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

5. Institute for Biocomputation and Complex Systems Physics (BIFI), University of Zaragoza, Zaragoza, Spain

6. Proteos, Inc, Kalamazoo, MI, USA

Publisher

IOS Press

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

Reference58 articles.

1. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030;Dorsey;Neurology,2007

2. The nigrostriatal system in Parkinson’s disease;Graybiel;Adv Neurol,1990

3. Axon degeneration in Parkinson’s disease;Burke;Exp Neurol,2013

4. Pathology and biology of the Lewy body;Pollanen;J Neuropathol Exp Neurol,1993

5. Alpha-synuclein in Lewy bodies;Spillantini;Nature,1997

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