N-Terminal Truncated Aβ4-42 Is a Substrate for Neprilysin Degradation in vitro and in vivo-Reference-Cited by-同舟云学术

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N-Terminal Truncated Aβ4-42 Is a Substrate for Neprilysin Degradation in vitro and in vivo

Published:2019-02-12 Issue:3 Volume:67 Page:849-858
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Hornung Karen¹,Zampar Silvia¹,Engel Nadine¹,Klafki Hans¹,Liepold Thomas²,Bayer Thomas A.¹,Wiltfang Jens¹³⁴,Jahn Olaf²,Wirths Oliver¹

Affiliation:

1. Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, Goettingen, Germany

2. Max Planck Institute of Experimental Medicine, Proteomics Group, Goettingen, Germany

3. German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany

4. Department of iBiMED, Medical Sciences, University of Aveiro, Aveiro, Portugal

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference42 articles.

1. Alzheimer’s disease as proteolytic disorders: Anabolism and catabolism of β-amyloid;Saido;Neurobiol Aging,1998

2. β-Amyloid catabolism: Roles for neprilysin (NEP) and other metallopeptidases?;Carson;J Neurochem,2002

3. Proteolytic degradation of amyloid β-protein;Saido;Cold Spring Harb Perspect Med,2012

4. Neutral endopeptidase can hydrolyze β-amyloid(1–40) but shows no effect on β-amyloid precursor protein metabolism;Howell;Peptides,1995

5. Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition;Iwata;Nat Med,2000

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2. Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice;Life;2023-04-20

3. Aβ31–35 Decreases Neprilysin-Mediated Alzheimer’s Amyloid-β Peptide Degradation;ACS Chemical Neuroscience;2021-09-10

4. N-Truncated Aβ Starting at Position Four—Biochemical Features, Preclinical Models, and Potential as Drug Target in Alzheimer’s Disease;Frontiers in Aging Neuroscience;2021-08-20

5. Physical activity and cognitive stimulation ameliorate learning and motor deficits in a transgenic mouse model of Alzheimer’s disease;Behavioural Brain Research;2021-01

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