Untangling the Role of Tau in Huntington’s Disease Pathology

Author:

Salem Shireen12,Cicchetti Francesca123

Affiliation:

1. Centre de Recherche du CHU de Québec, Axe Neurosciences, Québec, QC, Canada

2. Département de Médecine Moléculaire, Université Laval, Québec, QC, Canada

3. Département de Psychiatrie & Neurosciences, Université Laval, Québec, QC, Canada

Abstract

There is increasing evidence for the presence of pathological forms of tau in tissues of both Huntington’s disease (HD) patients and animal models of this condition. While cumulative studies of the past decade have led to the proposition that this disorder could also be considered a tauopathy, the implications of tau in cellular toxicity and consequent behavioral impairments are largely unknown. In fact, recent animal work has challenged the contributory role of tau in HD pathogenesis/pathophysiology. This review presents the supporting and opposing arguments for the involvement of tau in HD, highlighting the discrepancies that have emerged. Reflecting on what is known in other tauopathies, the putative mechanisms through which tau could initiate and/or contribute to pathology are discussed, shedding light on the future research directions that could be considered to confirm, or rule out, the clinical relevance of tau in HD.

Publisher

IOS Press

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

Reference87 articles.

1. The Huntington’s Disease Collaborative Research Grou;A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes;Cell,1993

2. Is Huntington’s disease a tauopathy;Gratuze;Brain,2016

3. Tau: A common denominator and therapeutic target for neurodegenerative disorders;Maxan;J Exp Neurosci,2380

4. Altered microtubule organization in small-calibre axons of mice lacking tau protein;Harada;Nature,1994

5. Nuclear tau, a key player in neuronal DNA protection;Sultan;J Biol Chem,2011

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3