Huntingtin Overexpression Does Not Alter Overall Survival in Murine Cancer Models-Reference-Cited by-同舟云学术

Huntingtin Overexpression Does Not Alter Overall Survival in Murine Cancer Models

Published:2022-12-16 Issue:4 Volume:11 Page:383-389
ISSN:1879-6397
Container-title:Journal of Huntington's Disease
language:
Short-container-title:JHD

Author:

Chan Laura Lynn¹,Hill Austin¹,Lu Ge¹,Van Raamsdonk Jeremy²³⁴,Gascoyne Randy⁵⁶,Hayden Michael R.¹,Leavitt Blair R.¹

Affiliation:

1. Department of Medical Genetics and Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada

2. Laboratory of Aging and Neurodegenerative Disease, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, USA

3. Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada

4. Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada

5. Center for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada

6. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

Abstract

A reduced incidence of various forms of cancer has been reported in Huntington’s disease patients and may be due to pro-apoptotic effects of mutant huntingtin. We tested this hypothesis by assessing the effects of huntingtin protein overexpression on survival in two murine cancer models. We generated YAC HD mice containing human huntingtin transgenes with various CAG tract lengths (YAC18, YAC72, YAC128) on either an Msh2 or p53 null background which have increased cancer incidence. In both mouse models of cancer, the overexpression of either mutant or wild-type huntingtin had no significant effect on overall survival. These results do not support the hypothesis that mutant huntingtin expression is protective against cancer.

Publisher

IOS Press

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

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