Speech Biomarkers in Huntington’s Disease: A Longitudinal Follow-Up Study in Premanifest Mutation Carriers-Reference-Cited by-同舟云学术

Speech Biomarkers in Huntington’s Disease: A Longitudinal Follow-Up Study in Premanifest Mutation Carriers

Published:2024-09-10 Issue:3 Volume:13 Page:369-373
ISSN:1879-6397
Container-title:Journal of Huntington's Disease
language:
Short-container-title:JHD

Author:

Saft Carsten¹,Jessen Julia¹,Hoffmann Rainer¹²,Lukas Carsten³,Skodda Sabine⁴

Affiliation:

1. Department of Neurology, Huntington-Centre NRW, St. Josef Hospital, Ruhr-University of Bochum, Bochum, Germany

2. Department of Neuropsychiatry, Huntington Centre South, kbo-Isar-Amper-Klinikum, Taufkirchen (Vils), Germany

3. Institute of Neuroradiology, St. Josef Hospital, Ruhr-University of Bochum, Bochum, Germany

4. Department of Neurology, Knappschaftskrankenhaus, Ruhr-University of Bochum, Bochum, Germany

Abstract

Speech alterations have been reported in manifest Huntington’s disease (HD) and premanifest mutation carriers (preHD). The aim of our study was to explore these alterations in preHD and whether they can be used as biomarkers. 13 preHD mutation carriers performed reading task, sustained phonation task and syllable repetition tasks at baseline and after 21 months, as well as clinical examination and MRI. Syllable repetition capacity and self-chosen velocity of single syllable repetition differed significantly between time points. There were no changes in clinical ratings or MRI volumetry. Measurements of speech might be sensitive tools for monitoring subclinical changes in preHD.

Publisher

IOS Press

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