Improved Brain Insulin/IGF Signaling and Reduced Neuroinflammation with T3D-959 in an Experimental Model of Sporadic Alzheimer’s Disease-Reference-Cited by-同舟云学术

Improved Brain Insulin/IGF Signaling and Reduced Neuroinflammation with T3D-959 in an Experimental Model of Sporadic Alzheimer’s Disease

Published:2016-11-19 Issue:2 Volume:55 Page:849-864
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

de la Monte Suzanne M.¹²³⁴⁵,Tong Ming¹²⁴,Schiano Irio⁶,Didsbury John⁷

Affiliation:

1. Liver Research Center, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA

2. Division of Gastroenterology, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA

3. Division of Neuropathology, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA

4. Department of Medicine, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA

5. Department of Pathology, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA

6. Quinnipiac University, Biomedical Sciences Department in Hamden, CT, USA

7. T3D Therapeutics, Inc., Research Triangle Park, NC, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference38 articles.

1. Epidemilogical trends strongly suggest exposures as etiologic agents in the pathogenesis of sporadic Alzheimer’s disease, diabetes mellitus, and non-alcoholic steatohepatitis;de la Monte;J Alzheimers Dis,2009

2. Brain insulin resistance and deficiency as therapeutic targets in Alzheimer’s disease;de la Monte;Curr Alzheimer Res,2012

3. Therapeutic targets of brain insulin resistance in sporadic Alzheimer’s disease;de la Monte;Front Biosci (Elite Ed),2012

4. Insulin resistance and neurodegeneration: Roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis;de la Monte;Curr Opin Investig Drugs,2009

5. Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline;Talbot;J Clin Invest,2012

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