Coexistence of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease: Case Report and Review of the Literature-Reference-Cited by-同舟云学术

Coexistence of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease: Case Report and Review of the Literature

Published:2023-10-10 Issue:4 Volume:95 Page:1383-1399
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Verde Federico¹²^ORCID,Aiello Edoardo Nicolò¹,Adobbati Laura¹,Poletti Barbara¹³,Solca Federica¹,Tiloca Cinzia¹,Sangalli Davide⁴,Maranzano Alessio¹,Muscio Cristina⁵,Ratti Antonia¹⁶,Zago Stefano⁷,Ticozzi Nicola¹²,Frisoni Giovanni Battista⁸,Silani Vincenzo¹²

Affiliation:

1. Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy

2. Department of Pathophysiology and Transplantation, “Dino Ferrari” Center, Università degli Studi di Milano, Milan, Italy

3. Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy

4. Department of Neurology and Stroke Unit, Azienda Socio Sanitaria Territoriale Lecco, Lecco, Italy

5. Neurology-5 (Neuropathology) Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

6. Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy

7. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

8. Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland

Abstract

We describe a case of amyotrophic lateral sclerosis (ALS) associated with Alzheimer’s disease (AD) and review the literature about the coexistence of the two entities, highlighting the following: mean age at onset is 63.8 years, with slight female predominance; ALS tends to manifest after cognitive impairment and often begins in the bulbar region; average disease duration is 3 years; cognitive phenotype is mostly amnestic; the pattern of brain involvement is, in most cases, consistent with AD. Our case and the reviewed ones suggest that patients with ALS and dementia lacking unequivocal features of FTD should undergo additional examinations in order to recognize AD.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference72 articles.

1. The frontotemporal dementia-motor neuron disease continuum;Burrell;Lancet,2016

2. Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria;Strong;Amyotroph Lateral Scler Frontotemporal Degener,2017

3. A case of Alzheimer’s disease with unusual neurological disturbances;Barrett;J Nerv Ment Dis,1913

4. Cognitive and behavioral involvement in ALS has been known for more than a century;Zago;Neurol Sci,2022

5. Association of amyotrophic lateral sclerosis and Alzheimer’s disease: New entity or coincidence? A case series;Vrillon;J Alzheimers Dis,2021

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Underestimated Relevance of Alzheimer’s Disease Copathology in Amyotrophic Lateral Sclerosis;Journal of Alzheimer's Disease;2023-10-10