Assessment of systemic administration of PEGylated IGF-1 in a mouse model of traumatic brain injury

Author:

Sama Diana M.1,Carlson Shaun W.12,Joseph Binoy1,Saenger Stefanie3,Metzger Friedrich34,Saatman Kathryn E.1

Affiliation:

1. Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, USA

2. Present address: Department of Neurological Surgery, Safar Center for Resuscitation Research, University of Pittsburgh, PA, USA

3. Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, Grenzacherstrasse, Basel, Switzerland

4. Versameb AG, Peter Merian-Strasse, Basel, Switzerland

Publisher

IOS Press

Subject

Neurology (clinical),Developmental Neuroscience,Neurology

Reference57 articles.

1. Regional distribution of fluoro-jade B staining in the hippocampus following traumatic brain injury;Anderson;Experimental Neurology,2005

2. IGF-1 protects dopamine neurons against oxidative stress: Association with changes in phosphokinases;Ayadi;Experimental Brain Research,2016

3. Blood brain barrier and neuroinflammation arecritical targets of IGF-1-mediated neuroprotection in stroke for middle-aged female rats.;Bake;PLoS One,2014

4. Conditional overexpression of insulin-like growth factor-1 enhances hippocampal neurogenesis and restores immature neuron dendritic processes after traumatic brain injury;Carlson;Journal of Neuropathology and Experimental Neurology,2014

5. Carlson S.W , & Saatman K.E. (2018). Central Infusion of IGF-1 Increases Hippocampal Neurogenesis and Improves Neurobehavioral Function after Traumatic Brain Injury.. Journal of Neurotrauma, April 2017. (Epub ahead of print).

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