Low Speech Connectedness in Alzheimer’s Disease is Associated with Poorer Semantic Memory Performance-Reference-Cited by-同舟云学术

Low Speech Connectedness in Alzheimer’s Disease is Associated with Poorer Semantic Memory Performance

Published:2021-08-03 Issue:3 Volume:82 Page:905-912
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Malcorra Bárbara Luzia Covatti¹,Mota Natália Bezerra²,Weissheimer Janaina³,Schilling Lucas Porcello⁴,Wilson Maximiliano Agustin⁵,Hübner Lilian Cristine⁶

Affiliation:

1. School of Humanities, Graduate Course in Linguistics, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil

2. Department of Physics, Federal University of Pernambuco (UFPE), Recife, PE, Brazil

3. Brain Institute, Department of Foreign Languages and Literatures, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil; CNPq - National Council for Scientific and Technological Development - Brasília, DF, Brazil

4. School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS); Brain Institute of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul (InsCer - PUCRS) - Porto Alegre, RS, Brazil; Neurology Service, São Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul (PUCRS) – Porto Alegre, RS, Brazil

5. Centre de recherche CERVO and Département de réadaptationé Laval, Québec City, QC, Canada

6. School of Humanities, Graduate Course in Linguistics, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil; CNPq - National Council for Scientific and Technological Development - Brasília, DF, Brazil

Abstract

Connected speech is an everyday activity. We aimed to investigate whether connected speech can differentiate oral narrative production between adults with Alzheimer’s disease (AD; n = 24) and cognitively healthy older adults (n = 48). We used graph attributes analysis to represent connected speech. Participants produced oral narratives and performed semantic, episodic, and working memory tasks. AD patients produced less connected narratives than cognitively healthy older adults. Connectedness was associated with semantic memory in AD and with episodic memory in controls. Word-graphs connectedness represents a practical tool to assess cognitive impairment in AD patients.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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