The Combination of Metabolic Posterior Cingulate Cortical Abnormalities and Structural Asymmetries Improves the Differential Diagnosis Between Primary Progressive Aphasia and Alzheimer’s Disease-Reference-Cited by-同舟云学术

The Combination of Metabolic Posterior Cingulate Cortical Abnormalities and Structural Asymmetries Improves the Differential Diagnosis Between Primary Progressive Aphasia and Alzheimer’s Disease

Published:2021-08-17 Issue:4 Volume:82 Page:1467-1473
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Mitolo Micaela¹,Stanzani-Maserati Michelangelo²,Manners David N.³,Capellari Sabina²³,Testa Claudia⁴,Talozzi Lia³,Poda Roberto²,Oppi Federico²,Evangelisti Stefania³,Gramegna Laura L.¹³,Magarelli Silvia⁵,Pantieri Roberta⁵,Liguori Rocco²³,Lodi Raffaele¹³,Tonon Caterina¹³

Affiliation:

1. Functional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, OUC Neurologia, Bologna, Italy

2. IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy

3. Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy

4. Department of Physics and Astronomy, University of Bologna, Bologna, Italy

5. IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neurologia, Bologna, Italy

Abstract

Differential diagnosis between primary progressive aphasia (PPA) and Alzheimer’s disease (AD) could be difficult if based on clinical grounds alone. We evaluated the combination of proton MR spectroscopy of posterior cingulate cortex (PCC) and quantitative structural imaging asymmetries to differentiate PPA from AD patients. A greater left-lateralized temporo-parietal atrophy (higher accuracy for the PCC, 81.4%) and metabolic neurodegenerative changes in PCC (accuracy 76.8%) was demonstrated in PPA versus AD. The combined multiparametric approach increased the accuracy to 94%in the differential diagnosis between these two neurodegenerative diseases.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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