The Israel Registry for Alzheimer’s Prevention (IRAP) Study: Design and Baseline Characteristics

Author:

Ravona-Springer Ramit123,Sharvit-Ginon Inbal1,Ganmore Ithamar1234,Greenbaum Lior135,Bendlin Barbara B.6,Sternberg Shelley A.7,Livny Abigail138,Domachevsky Liran38,Sandler Israel8,Ben Haim Simona910,Golan Sapir1,Ben-Ami Liat18,Lesman-Segev Orit8,Manzali Sigalit111,Heymann Anthony37,Beeri Michal Schnaider112

Affiliation:

1. The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel

2. Memory Clinic, Sheba Medical Center, Tel Hashomer, Israel

3. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

4. Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel

5. The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel

6. Wisconsin Alzheimer’s Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA

7. Maccabi Healthcare Services, Israel

8. Department of Diagnostic imaging, Seba Medical Center, Tel Hashomer, Israel

9. Department of Medical Biophysics and Nuclear Medicine, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel

10. Institute of Nuclear Medicine, University College London and UCL Hospitals, NHS Trust, London, UK

11. Department of Pathology, Sheba Medical Center, Tel-Hashomer, Israel

12. Department of Psychiatry, The Icahn School of Medicine at Mount Sinai, New York, NY, USA

Abstract

Background: Family history of Alzheimer’s disease (AD) is associated with increased dementia-risk. Objective: The Israel Registry for Alzheimer’s Prevention (IRAP) is a prospective longitudinal study of asymptomatic middle-aged offspring of AD patients (family history positive; FH+) and controls (whose parents have aged without dementia; FH–) aimed to unravel the contribution of midlife factors to future cognitive decline and dementia. Here we present the study design, methods, and baseline characteristics. Methods: Participants are members of the Maccabi Health Services, 40–65 years of age, with exquisitely detailed laboratory, medical diagnoses and medication data available in the Maccabi electronic medical records since 1998. Data collected through IRAP include genetic, sociodemographic, cognitive, brain imaging, lifestyle, and health-related characteristics at baseline and every three years thereafter. Results: Currently IRAP has 483 participants [mean age 54.95 (SD = 6.68) and 64.8% (n = 313) women], 379 (78.5%) FH+, and 104 (21.5%) FH–. Compared to FH–, FH+ participants were younger (p = 0.011), more often males (p = 0.003) and with a higher prevalence of the APOE E4 allele carriers (32.9% FH+, 22% FH–; p = 0.040). Adjusting for age, sex, and education, FH+ performed worse than FH–in global cognition (p = 0.027) and episodic memory (p = 0.022). Conclusion: Lower cognitive scores and higher rates of the APOE E4 allele carriers among the FH+ group suggest that FH ascertainment is good. The combination of long-term historical health-related data available through Maccabi with the multifactorial information collected through IRAP will potentially enable development of dementia-prevention strategies already in midlife, a critical period in terms of risk factor exposure and initiation of AD-neuropathology.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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