Longitudinal Study of SNCA Rep1 Polymorphism on Executive Function in Early Parkinson’s Disease-Reference-Cited by-同舟云学术

Longitudinal Study of SNCA Rep1 Polymorphism on Executive Function in Early Parkinson’s Disease

Published:2022-04-05 Issue:3 Volume:12 Page:865-870
ISSN:1877-7171
Container-title:Journal of Parkinson's Disease
language:
Short-container-title:JPD

Author:

Tan Yi Jayne¹²,Saffari Seyed Ehsan¹³,Zhao Yi⁴,Ng Ebonne Y.L.²⁵,Yong Alisa C.W.¹²,Ng Samuel Y.E.¹²,Chia Nicole S.Y.¹²,Choi Xinyi²⁵,Heng Dede²⁵,Neo Shermyn¹²,Xu Zheyu¹²,Tay Kay Yaw¹²,Au Wing Lok¹²,Tan Eng-King²⁵⁶,Tan Louis C.S.¹²,Ng Adeline S.L.¹²⁶

Affiliation:

1. Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore

2. Parkinson’s Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore

3. Center for Quantitative Medicine, Duke-NUS Medical School, National University of Singapore, Singapore

4. Department of Clinical Translational Research, Singapore General Hospital, Singapore

5. Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore

6. Neuroscience and Behavioural Disorders Program, Duke-NUS Medical School, Singapore

Abstract

The alpha-synuclein gene promoter (SNCA-Rep1) is associated with Parkinson’s disease (PD), but its relationship with performance across individual cognitive domains in early PD is unknown. This study aims to investigate Rep1 polymorphism and longitudinal change in cognition in early PD. In this longitudinal study, Rep1 allele lengths (“long” and “short”) were determined in 204 early PD patients. All participants underwent annual neuropsychological assessments and followed up for 3 years. Linear-mixed model was performed to investigate the association of Rep1 status and longitudinal change in individual cognitive domains. At 3 years, significant decline in executive function was observed in long Rep1 allele carriers vs short allele carriers, controlling for potential confounders. This is the first longitudinal study demonstrating that long Rep1 allele carriers are at higher risk for executive dysfunction in early PD.

Publisher

IOS Press

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

Reference40 articles.

1. Cognitive decline in Parkinson disease;Aarsland;Nat Rev Neurol,2017

2. alpha-Synuclein locus triplication causes Parkinson’s disease;Singleton;Science,2003

3. Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain;Cronin;Hum Mol Genet,2009

4. alpha-Synuclein gene haplotypes are associated with Parkinson’s disease;Farrer;Hum Mol Genet,2001

5. alpha-Synuclein promoter confers susceptibility to Parkinson’s disease;Pals;Ann Neurol,2004