A Primer on the Evolution of Aducanumab: The First Antibody Approved for Treatment of Alzheimer’s Disease

Author:

Mukhopadhyay Sanchari1ORCID,Banerjee Debanjan1ORCID

Affiliation:

1. Geriatric Unit, Department of Psychiatry, NationalInstitute of Mental Health and Neurosciences, Bengaluru, Karnataka, India

Abstract

Alzheimer’s disease (AD) is the most common form of dementia with global burden projected to triple by 2050. It incurs significant biopsychosocial burden worldwide with limited treatment options. Aducanumab is the first monoclonal antibody recently approved by the US-FDA for mild AD through the accelerated approval pathway. It is the first molecule to be approved for AD since 2003 and carries with it a therapeutic promise for the future. As the definition of AD has evolved from a pathological entity to a Clinico-biological construct over the years, the amyloid-β (Aβ) pathway has been increasingly implicated in its pathogenesis. The approval of Aducanumab is based on reduction of the Aβ load in the brain, which forms a surrogate marker for this pathway. The research populace has, however, been globally divided by skepticism and hope regarding this approval. Failure to meet clinical endpoints in the trials, alleged transparency issues, cost-effectiveness, potential adverse effects, need for regular monitoring, and critique of ‘amyloid cascade hypothesis’ itself are the main caveats concerning the antibody. With this controversy in background, this paper critically looks at antibody research in AD therapeutics, evidence, and evolution of Aducanumab as a drug and the potential clinical implications of its use in future. While the efficacy of this monoclonal antibody in AD stands as a test of time, based on the growing evidence it is vital to rethink and explore alternate pathways of pathogenesis (oxidative stress, neuroinflammation, cholesterol metabolism, vascular factors, etc.) as possible therapeutic targets that may help elucidate the enigma of this complex yet progressive and debilitating neurodegenerative disorder.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference71 articles.

1. 2020 Alzheimer’s disease facts and figures;Alzheimer’s Association;Alzheimers Dement,2020

2. Alzheimer’sdisease;Scheltens;Lancet,2021

3. Global, regional, and national burden of Alzheimer’s disease andother dementias, 1990-2016: A systematic analysis for the GlobalBurden of Disease Study 2016;Nichols;Lancet Neurol,2019

4. Drugs for Alzheimer’s disease: Are they effective?;Casey;P T,2010

5. Alzheimer’s disease: The amyloid cascade hypothesis;Hardy;Science,1992

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