A Mutation in the Mitochondrial Aspartate/Glutamate Carrier Leads to a More Oxidizing Intramitochondrial Environment and an Inflammatory Myopathy in Dutch Shepherd Dogs

Author:

Shelton G. Diane1,Minor Katie M.2,Li Kefeng3,Naviaux Jane C.4,Monk Jon3,Wang Lin3,Guzik Elizabeth2,Guo Ling T.1,Porcelli Vito5,Gorgoglione Ruggiero5,Lasorsa Francesco M.6,Leegwater Peter J.7,Persico Antonio M.8,Mickelson James R.2,Palmieri Luigi56,Naviaux Robert K.13910

Affiliation:

1. Department of Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA

2. Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, USA

3. The Mitochondrial and Metabolic Disease Center, School of Medicine, University of California San Diego, San Diego, CA, USA

4. Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA, USA

5. Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari Aldo Moro, Bari, Italy

6. Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, Consiglio Nazionale delle Ricerche, Bari, Italy

7. Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, 3508, The Netherlands

8. Interdepartmental Program “Autism 0–90”, “G. Martino” Hospital, University of Messina, Messina, Italy

9. Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA

10. Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA

Publisher

IOS Press

Subject

Clinical Neurology,Neurology

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