Amyloid-Related Imaging Abnormalities (ARIA) in Immunotherapy Trials for Alzheimer’s Disease: Need for Prognostic Biomarkers?

Author:

Piazza Fabrizio123,Winblad Bengt4

Affiliation:

1. The inflammatory cerebral amyloid angiopathy and Alzheimer’s disease βiomarkers (iCAβ) International Network, Monza, Italy

2. The iCAβ-ITALY Study Group of the Italian Society for the study of Dementia (SINdem), Italy

3. School of Medicine and Surgery, Milan Center for Neuroscience (NeuroMi), University of Milano-Bicocca, Monza, Italy

4. Karolinska Institutet, Department of NVS, Center for Alzheimer Research, Division of Neurogeriatrics, Huddinge, Sweden

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference16 articles.

1. MR imaging features of amyloid-related imaging abnormalities;Barakos;AJNR Am J Neuroradiol,2013

2. Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup;Sperling;Alzheimers Dement,2011

3. Anti-Abeta autoantibodies in amyloid related imaging abnormalities (ARIA): Candidate biomarker for immunotherapy in Alzheimer’s disease and cerebral amyloid angiopathy;DiFrancesco;Frontiers Neurol,2015

4. OC4: Efficacy and safety of gantenerumab from the phase 3 SCarlet RoAD trial, a study of gantenerumab in patients with prodromal AD;Lasser;J Prev Alzheimers Dis,2015

5. OC5: CSF and amyloid PET biomarker data from the phase 3 SCarlet RoAD trial, a study of gantenerumab in patients with prodromal AD;Nikolcheva;J Prev Alzheimers Dis,2015

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