Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer’s Disease: The Role of APP

Author:

Doran Eric1,Keator David2,Head Elizabeth3,Phelan Michael J.4,Kim Ron5,Totoiu Minodora1,Barrio Jorge R.6,Small Gary W.7,Potkin Steven G.2,Lott Ira T.1

Affiliation:

1. Department of Pediatrics, University of California, Irvine Medical Center, Orange, CA, USA

2. Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA

3. Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA

4. Department of Statistics, University of California, Irvine, CA, USA

5. Department of Pathology, University of California, Irvine Medical Center, Orange, CA, USA

6. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA, USA

7. Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference69 articles.

1. Alzheimer’s disease and Down’s syndrome;Mann;Histopathology,1988

2. The epidemiology of Alzheimer disease in intellectual disability: Results and recommendations from an international conference;Zigman;J Intellect Disabil Res,1997

3. Genetic and host factors for dementia in Down’s syndrome;Schupf;Br J Psychiatry,2002

4. Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype;Korenberg;Am J Hum Genet,1990

5. A genetic cause of Alzheimer disease: Mechanistic insights from Down syndrome;Wiseman;Nat Rev Neurosci,2015

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