Frequency of Depressive Disorders in Parkinson’s Disease: A Systematic Review and Meta-Analysis

Author:

Chendo Ines123,Silva Carlos1,Duarte Gonçalo S.45,Prada Luisa45,Vian João6,Quintão Ana6,Voon Valerie7,Ferreira Joaquim J.345

Affiliation:

1. Psychiatry Department, Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal

2. Clínica Universitária de Psiquiatria e Psicologia Médica, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal

3. CNS – Campus Neurológico, Torres Vedras, Portugal

4. Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal

5. Instituto de Medicina Molecular João Lobo Antunes, Lisbon, Portugal

6. Department of Psychiatry, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal

7. Department of Psychiatry, University of Cambridge, Cambridge, UK

Abstract

Background: Depressive disorders are recognized as a common neuropsychiatric disorder of Parkinson’s disease (PD). Reported frequencies vary widely among studies and depend on the diagnostic criteria, the methods of ascertainment used, and the population sampled. Objective: We aimed to evaluate the frequency of depressive disorders in PD and to investigate the relationship with PD clinical variables. Methods: A systematic review and meta-analysis of observational studies (community-based, prospective and retrospective cohort, case-control, and cross-sectional studies) reporting the frequency of depressive disorders in PD patients. Results: Electronic database search wielded 3,536 articles; an additional 91 were identified through citation chaining. 163 full-text articles were assessed for eligibility. Of these, 49 met the inclusion criteria for our analysis. The pooled frequency of depressive disorders was 30.7% (95% confidence interval [CI] 25.6 to 36.2; I2 = 95%; 49 studies; combined n = 10,039). The pooled frequency of major depressive disorder was 14.0% (95% CI 10.5 to 18.5; I2 = 88%; 23 studies; combined n = 5,218). Subgroup/meta-regression analyses were conducted to investigate the relationship between frequency and study inclusion criteria, methodology used for diagnosis, and study design. We found a statistically significant correlation between study design and depressive disorders frequency (ranging from 8% in the community-based study to 44% in the retrospective studies) and a statistically significant positive correlation between mean baseline PD duration and major depressive disorder frequency. Conclusion: The current meta-analysis found a global frequency of depressive disorders of 30.7% and major depressive disorder of 14.0%. Study design influenced the frequency of depressive disorders in PD. Mean baseline PD duration and major depressive disorder frequency were positively correlated.

Publisher

IOS Press

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

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