Curcumin Downregulates GSK3 and Cdk5 in Scopolamine-Induced Alzheimer’s Disease Rats Abrogating Aβ40/42 and Tau Hyperphosphorylation

Author:

Das Tushar Kanti12,Jana Piyali3,Chakrabarti Swarup Kumar2,Abdul Hamid Mas R.W.1

Affiliation:

1. Universiti Brunei Darussalam, PAPRSB Institute of Health Sciences, Jalan Tungku Link, Gadong, Brunei Darussalam

2. Institute of Reproductive Medicine, Salt Lake, Kolkata, India

3. Department of Microbiology, Vidyasagar University, India

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Neuroscience

Reference32 articles.

1. The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation;Plattner;J Biol Chem,2006

2. Potential of glycowithanolides from(Ashwagandha) as therapeutic agents for the treatment of Alzheimer’s disease;Das;World J Pharm Res,2015

3. CDK5 activator protein p25 preferentially binds and activates GSK3β;Chow;Proc Natl Acad Sci U S A,2014

4. Cdk5 activity in the brain – multiple paths of regulation;Shah;J Cell Sci,2014

5. Deregulated Cdk5 activity is involved in inducing Alzheimer’s disease;Shukla;Arch Med Res,2012

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