Preliminary study on the effect of ozone exposure on blood glucose level in rats

Abstract

BACKGROUND: In recent years, people have paid more and more attention to the health hazards caused by O3 exposure, which will become a major problem after fine particulate matter (PM). OBJECTIVE: To investigate the effects of ozone (O3) exposure on blood glucose levels in rats under different concentrations and times. METHODS: Eighty rats were divided into control group and three ozone concentration groups. Each group was continuously exposed for 1d, 3d and, 6d, and exposed for 6 hours daily. After exposure, GTT, FBG, and random blood glucose were measured. RESULTS: The FBG value increased significantly on the 6th day of 0.5 ppm and the 3rd and 6th days of 1.0 ppm exposure compared with the control group (P< 0.05). The random blood glucose value was significantly increased on the 3rd and 6th days of each exposure concentration (P< 0.05). When exposed to 1 ppm concentration, the 120 min GTT value of 1 d, 3 d and, 6 d was significantly higher than that of the control group (P< 0.05). CONCLUSION: After acute O3 exposure, the blood glucose level of rats was affected by the exposure concentration and time. The concentration of 0.1 ppm had no significant impact on FBG and random blood glucose, and O3 with a concentration of 0.1 ppm and 0.5 ppm had no significant impact on values of GTT at 90 min, and 120 min.