PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer’s Disease and Multiple Sclerosis-Reference-Cited by-同舟云学术

PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer’s Disease and Multiple Sclerosis

Published:2021-03-09 Issue:1 Volume:80 Page:71-77
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Chen Fan¹,Zhang Yan²,Wang Longcai³,Wang Tao⁴⁵,Han Zhifa⁶⁷⁸,Zhang Haihua⁹,Gao Shan⁹,Hu Yang⁹¹⁰,Liu Guiyou¹⁹¹¹

Affiliation:

1. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China

2. Department of Pathology, The Affiliated Hospital of Weifang Medical University, Weifang, China

3. Department of Anesthesiology, The Affiliated Hospital of Weifang Medical University, Weifang, China

4. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China

5. Chinese Institute for Brain Research, Beijing, China

6. School of Medicine, School of Pharmaceutical Sciences, THU-PKU Center for Life Sciences, Tsinghua University, Beijing, China

7. State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China

8. Department of Pathophysiology, Peking Union Medical College, Beijing, China

9. Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China

10. School of Life Science and Technology, Harbin Institute of Technology, Harbin, China

11. National Engineering Laboratory of Internet Medical Diagnosis and Treatment Technology, Xuanwu Hospital, Capital Medical University, Beijing, China

Abstract

We aimed to evaluate the association of PLCG2 rs72824905 variant with Alzheimer’s disease (AD) and multiple sclerosis (MS) using large-scale genetic association study datasets. We selected 50,024 AD cases and 467,330 controls, and 32,367 MS cases and 36,012 controls. We found moderate heterogeneity of rs72824905 in different studies. We found significant association between rs72824905 G allele and reduced AD risk (OR = 0.66, 95% CI 0.59–0.74, p = 5.91E-14). Importantly, rs72824905 G allele could also significantly reduce the risk of MS with OR = 0.94, p = 3.63E-05. Hence, the effects of rs72824905 on AD and MS are consistent.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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3. PLCγ2 impacts microglia-related effectors revealing variants and pathways important in Alzheimer’s disease;Frontiers in Cell and Developmental Biology;2022-09-06

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