Two-Year Changes in Physical Activity and Concurrent Changes in Cognitive Function in a Cohort of Adults with Metabolic Syndrome-Reference-Cited by-同舟云学术

Two-Year Changes in Physical Activity and Concurrent Changes in Cognitive Function in a Cohort of Adults with Metabolic Syndrome

Published:2023-09-26 Issue:3 Volume:95 Page:887-899
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Rognoni Teresa¹,Fernández-Matarrubia Marta²,Martinez-González Miguel Ángel³⁴⁵⁶,Salas-Salvadó Jordi⁵⁷⁸,Corella Dolores⁵⁹,Castañer Olga¹⁰¹¹,Martínez J. Alfredo⁵¹²¹³,Alonso-Gómez Ángel M.⁵¹⁴,Gómez-Gracia Enrique¹⁵,Vioque Jesús¹¹¹⁶,Romaguera Dora⁵¹⁷,López-Miranda José⁵¹⁸,Estruch Ramón⁵¹⁹,Tinahones Francisco J.⁵²⁰,Santos-Lozano José Manuel⁵²¹,Serra-Majem Lluis⁵²²,Cano Ibañez Naomi¹¹²³²⁴,Tur Josep A.⁵²⁵,Micó Pérez Rafael¹¹²⁶,Pintó Xavier⁵²⁷,Delgado-Rodríguez Miguel¹¹²⁸,Ortiz Ramos María²⁹,Vidal Josep³⁰³¹,Vázquez Clotilde⁵³²,Daimiel Lidia⁵¹³³³,Ros Emilio⁵³⁰,Goñi-Ruiz Nuria⁵³⁴,Babio Nancy⁵⁷⁸,Sorlí José V.⁵⁹,Schröder Helmut¹⁰¹¹,García-Rios Antonio⁵¹⁸,Compañ-Gabucio Laura¹⁶,Warnberg Julia³⁵³⁶,Zulet M. Ángeles⁴⁵¹²,Chaplin Alice⁵¹⁷,Sacanella Emilio⁵¹⁹,Bouzalmate-Hajjaj Amira¹¹²³,Tojal-Sierra Lucas⁵¹⁴,Damas-Fuentes Miguel⁵²⁰,Vázquez Zenaida³⁵,Gómez-Martínez Carlos⁵⁷⁸,Saiz Carmen⁵⁹,Malcampo Mireia¹⁰,Ortiz-Morales Ana M.⁵¹⁸,Martínez-Avilés Vanessa³⁷,García-Gavilan Jesús⁵⁷⁸,Abete Itziar⁴⁵¹²,Fitó Montserrat⁵¹⁰,Toledo Estefanía³⁴⁵

Affiliation:

1. Department of Neurology, Clínica Universidad de Navarra, Madrid, Spain

2. Department of Neurology, Marqués de Valdecilla University Hospital, Santander, Spain

3. Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain

4. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain

5. Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain

6. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA

7. Universitat Rovira i Vigili, Department de Bioquímica i Biotecnología, Unitat de Nutrició Humana, Reus, Spain

8. Institut d'Investigació Sanitària Pere i Virgili (IISPV), Hospital San Joan de Reus, Reus, Spain

9. Department of Preventive Medicine, University of Valencia, Valencia, Spain

10. Cardiovascular Risk and Nutrition, Hospital del Mar Research Institute (IMIM), Barcelona, Spain

11. Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III, Madrid, Spain

12. Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain

13. Nutritional Control of the Epigenome Group, Precision Nutrition and Obesity Program, IMDEA Food, CEI UAM + CSIC, Madrid, Spain

14. Bioaraba Health Research Institute, Cardiovascular, Respiratory and Metabolic Area; Osakidetza Basque Health Service, Araba University Hospital; University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain

15. Department of Preventive Medicine and Public Health, Instituto de Investigación Biomédica de Málaga-IBIMA, School of Medicine, University of Málaga, Málaga, Spain

16. Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernández (ISABIAL-UMH).Alicante, Spain

17. Research Group on Nutritional Epidemiology & Cardiovascular Physiopathology (NUTRECOR), HealthResearch Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain

18. Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain

19. Department of Internal Medicine, Institut de I’nvestigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain

20. Department of Endocrinology, Virgen de la Victoria Hospital, Instituto de Investigación Biomédica de Málaga (IBIMA). University of Málaga, Málaga, Spain

21. Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, Sevilla, Spain

22. Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria and Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, Las Palmas de Gran Canaria, Spain

23. Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain

24. Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain

25. Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, Palma de Mallorca, Spain

26. Institute of Biomedicine (IBIOMED), University of León, León, Spain

27. Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Spain

28. Division of Preventive Medicine, Faculty of Medicine, University of Jaén, Jaén, Spain

29. Department of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Madrid, Spain

30. Lipid Clinic, Department of Endocrinology and Nutrition, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain

31. CIBER Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain

32. Department of Endocrinology and Nutrition, Hospital Fundación Jiménez Díaz, Instituto de Investigaciones Biomédicas IISFJD, University Autónoma, Madrid, Spain

33. Departamento de Ciencias Farmacéuticas y de la Salud, Faculty de Farmacia, Universidad San Pablo-CEU, CEU Universities, Boadilla del Monte, Spain

34. Servicios de Atención Primaria, Navarra Regional Health Service (Osasunbidea), Pamplona, Spain

35. Department of Nursing, School of Health Sciences University of Malaga, Spain

36. Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain

37. Centro de Salud Raval de Elche, Alicante, Spain

Abstract

Background: It has been proposed that physical activity (PA) could prevent cognitive decline. Objective: To evaluate the association between changes in PA and changes in cognitive function in a cohort of adults with metabolic syndrome. Methods: Longitudinal observational study including 5,500 adults (mean age 65 years, SD = 5; women = 49.3% ) with metabolic syndrome. Participants underwent physical activity measurements and cognitive evaluation at baseline and at two-years of follow-up. PA was quantified using the Minnesota questionnaire-shortened version. Cognitive function was evaluated using a battery of tests: Mini-Mental Test Examination, Clock Drawing Test, Trail Making Test A and B, Verbal Fluency Test, and Digit Span. The primary outcome was two-year change in cognition, measured through the Global Composite Score (GCS) of all neuropsychological tests. Multivariable-adjusted linear regression models were fitted with baseline PA and their changes as the main exposures and changes in cognitive function as the outcome. Results: No significant association was found between PA levels (or their changes) in the GCS of cognitive function. A greater increase in PA levels was associated with a more favorable two-year change in the Trail Making Test A (Q4 versus Q1: b = – 2.24s, 95% CI –4.36 to –0.12s; p-trend = 0.020). No significant association was found for other neuropsychological test. Conclusion: Our results do not support an association between increases in PA and the evolution of the global cognitive function at two-year in an intervention trial which included PA promotion in one of its two randomized arms, but they suggested a possible beneficial effect of PA on attentional function in older adults.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference45 articles.

1. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the Global Burden of Disease Study 2019;GBD 2019 Dementia Forecasting Collaborators;Lancet Public Health,2022

2. Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016;GBD 2016 Dementia Collaborators;Lancet Neurol,2016

3. A Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium;Wolters;Neurology,2020

4. The changing prevalence and incidence of dementia over time-current evidence;Wu;Nat Rev Neurol,2017

5. Potential for primary prevention of Alzheimer’s disease: An analysis of population-based data;Norton;Lancet Neurol,2014