The expression of programmed death-ligand 1 and its association with histopathological grade, stage of disease, and occurrence of metastasis in breast cancer-Reference-Cited by-同舟云学术

The expression of programmed death-ligand 1 and its association with histopathological grade, stage of disease, and occurrence of metastasis in breast cancer

Published:2021-06-25 Issue: Volume:40 Page:S71-S76
ISSN:0888-6008
Container-title:Breast Disease
language:
Short-container-title:BD

Author:

Pranoto Agung Sindu¹,Haryasena Haryasena¹,Prihantono Prihantono²,Rahman Septiman¹,Sampepajung Daniel¹,Indra Indra¹,Syamsu Salman Ardy¹,Sampepajung Elridho¹,Nelwan Berti Julian²,Faruk Muhammad²

Affiliation:

1. , , , Hasanuddin University, , Indonesia

2. , , Hasanuddin University, , Indonesia

Abstract

INTRODUCTION: Programmed death ligand 1 (PD-L1) plays a role in tumor escape and progression by inactivating T lymphocytes. The aim of the study reported here was to determine the relationship between the expression of PD-L1 and histopathological grade, stage of disease, and the occurrence of metastasis in breast cancer. METHODS: The observational cross-sectional study involved analyzing the expression of PD-L1 by immunohistochemistry. RESULTS: PD-LI was expressed in 43 of 60 patients with breast cancer (71.6%), mostly with a moderate histopathological grade (58.3%) and at an advanced stage (50%). Associations between the expression of PD-L1 and histopathological grade (p = 0.011), stage of disease (p = 0.009), and the occurrence of metastasis (p = 0.01) were significant, with an odds ratio of 5. CONCLUSION: The associations between the expression of PD-L1 and histopathological grade, disease stage, and occurrence of metastasis were all significant in cases of breast cancer in the sample. Those findings suggest that the expression of PD-L1 increases the progression of breast cancer.

Publisher

IOS Press

Subject

Cancer Research,Oncology,General Medicine

Reference27 articles.

1. A Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries;Bray;CA Cancer J Clin,2018

2. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012;Ferlay;Int J Cancer,2015

3. Juvenile phyllodes tumor of the breast;Prihantono;J Pediatr Surg Case Rep,2020

4. Hallmarks of cancer: The next generation;Hanahan;Cell,2011

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cancer immunoediting, PD-L1 expression, CTLA-4 and CD8+ tumor-infiltrating lymphocyte density, and chemoradiotherapy in nasopharyngeal carcinoma;Chirurgia;2024-09

2. The relationship of changes in molecular subtypes with metastases and progression-free survival in breast cancer;Breast Disease;2024-04-25

3. Comparison of tumor size, histopathological grade, and molecular subtype of breast cancer at a single center study;Breast Disease;2023-06-30

4. Vascular endothelial growth factor-A expression is significantly correlated with HER2 expression in late-stage breast cancer patients;Breast Disease;2023-01-03

5. Evaluation of breast cancer metastasis and mortality rates based on molecular subtype: A description study;Breast Disease;2022-12-28