Working Memory Training Responsiveness in Parkinson’s Disease Is Not Determined by Cortical Thickness or White Matter Lesions-Reference-Cited by-同舟云学术

Working Memory Training Responsiveness in Parkinson’s Disease Is Not Determined by Cortical Thickness or White Matter Lesions

Published:2024-03-05 Issue:2 Volume:14 Page:347-351
ISSN:1877-7171
Container-title:Journal of Parkinson's Disease
language:
Short-container-title:JPD

Author:

Giehl Kathrin¹²,Theis Hendrik¹³,Ophey Anja⁴,Hammes Jochen¹⁵,Reker Paul³,Eggers Carsten⁶,Fink Gereon R.³⁷,Kalbe Elke⁴,van Eimeren Thilo¹³

Affiliation:

1. Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Multimodal Neuroimaging Group, Cologne, Germany

2. Research Center Jülich, Institute for Neuroscience and Medicine (INM-2), Jülich, Germany

3. Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

4. Department of Medical Psychology, Faculty of Medicine and University Hospital Cologne, Neuropsychology and Gender Studies and Center for Neuropsychological Diagnostics and Intervention (CeNDI), University of Cologne, Cologne, Germany

5. Nuklearmedizin, Radiologische Allianz, Hamburg, Germany

6. Department of Neurology, Knappschaftskrankenhaus Bottrop, Bottrop, Germany

7. Research Center Jülich, Institute for Neuroscience and Medicine (INM-3), Jülich, Germany

Abstract

Patients with Parkinson’s disease are highly vulnerable for cognitive decline. Thus, early intervention by means of working memory training (WMT) may be effective for the preservation of cognition. However, the influence of structural brain properties, i.e., cortical thickness and volume of white matter lesions on training responsiveness have not been studied. Here, behavioral and neuroimaging data of 46 patients with Parkinson’s disease, 21 of whom engaged in home-based, computerized adaptive WMT, was analyzed. While cortical thickness and white matter lesions volume were associated with cognitive performance at baseline, these structural brain properties do not seem to determine WMT responsiveness.

Publisher

IOS Press

Reference12 articles.

1. Reviewing working memory training gains in healthy older adults: A meta-analytic review of transfer for cognitive outcomes;Teixeira-Santos;Neurosci Biobehav Rev,2019

2. Predicting working memory training responsiveness in Parkinson’s disease: Both “system hardware” and room for improvement are needed;Ophey;Neurorehabil Neural Repair,2021

3. Effects of working memory training in patients with Parkinson’s disease without cognitive impairment: A randomized controlled trial;Ophey;Parkinsonism Relat Disord,2020

4. Effects of home-based working memory training on visuo-spatial working memory in Parkinson’s disease: A randomized controlled trial;Giehl;J Cent Nerv Syst Dis,2020

5. Vascular risk factors, white matter lesions and cognitive impairment in Parkinson’s disease: The PACOS longitudinal study;Nicoletti;J Neurol,2021