Roles of Non-Coding RNAs as Novel Diagnostic Biomarkers in Parkinson’s Disease-Reference-Cited by-同舟云学术

Roles of Non-Coding RNAs as Novel Diagnostic Biomarkers in Parkinson’s Disease

Published:2021-10-12 Issue:4 Volume:11 Page:1475-1489
ISSN:1877-7171
Container-title:Journal of Parkinson's Disease
language:
Short-container-title:JPD

Author:

Manna Ida¹^ORCID,Quattrone Andrea²,De Benedittis Selene³,Iaccino Enrico⁴,Quattrone Aldo¹⁵

Affiliation:

1. Institute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Section of Germaneto, Catanzaro, Italy

2. Department of Medical and Surgical Sciences, Institute of Neurology, University “Magna Graecia, ” Germaneto, Catanzaro, Italy

3. Department of Medical and Surgical Sciences, University “Magna Graecia, ” Germaneto, Catanzaro, Italy

4. Department of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, Catanzaro, Italy

5. Neuroscience Research Center, University “Magna Graecia”, Catanzaro, Italy

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting 5%of the elderly population. Currently, the diagnosis of PD is mainly based on clinical features and no definitive diagnostic biomarkers have been identified. The discovery of biomarkers at the earliest stages of PD is of extreme interest. This review focuses on the current findings in the field of circulating non-coding RNAs in PD. We briefly describe the more established circulating biomarkers in PD and provide a more thorough review of non-coding RNAs, in particular microRNAs, long non-coding RNAs and circular RNAs, differentially expressed in PD, highlighting their potential for being considered as biomarkers for diagnosis. Together, these studies hold promise for the use of peripheral biomarkers for the diagnosis of PD.

Publisher

IOS Press

Subject

Cellular and Molecular Neuroscience,Clinical Neurology

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