Correlation of Blood Metal Concentrations with Cognitive Scores and Neuroimaging Findings in Patients with Total Joint Arthroplasty-Reference-Cited by-同舟云学术

Correlation of Blood Metal Concentrations with Cognitive Scores and Neuroimaging Findings in Patients with Total Joint Arthroplasty

Published:2023-08-15 Issue:4 Volume:94 Page:1335-1342
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Beba Alican¹²,Peterson Stephanie M.²,Brennan Peter C.³,O’Byrne Jamie²,Machulda Mary M.⁴,Jannetto Paul J.⁵,Vemuri Prashanthi⁶,Lewallen David G.³,Maradit Kremers Hilal²³,Vassilaki Maria²

Affiliation:

1. George Washington University, Columbian College of Arts and Sciences, Washington, DC, USA

2. Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA

3. Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA

4. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA

5. Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN, USA

6. Department of Radiology, Mayo Clinic, Rochester, MN, USA

Abstract

Total joint arthroplasty (TJA) implants are composed of metals, ceramics, and/or polyethylene. Studies suggest that the debris released from metal implants may possess neurotoxic properties with reports of neuropsychiatric symptoms and memory deficits, which could be relevant to Alzheimer’s disease and related dementias. This exploratory study examined the cross-sectional correlation of blood metal concentrations with cognitive performance and neuroimaging findings in a convenience sample of 113 TJA patients with history of elevated blood metal concentrations of either titanium, cobalt and/or chromium. Associations with neuroimaging measures were observed but not with cognitive scores. Larger studies with longitudinal follow-up are warranted.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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