Dendritic cells: Pivotal antigen presenting cells in periodontal disease

Abstract

 Periodontal disease is a common oral health condition that is characterized by chronic inflammation, tissue destruction, and bone loss. Dendritic cells (DCs) play a critical role in the pathogenesis of periodontal disease by recognizing and capturing antigens from bacterial biofilms, initiating and regulating the immune response, promoting inflammation and tissue destruction, and regulating bone resorption. Dysregulation of DC function can lead to excessive inflammation and tissue destruction, which are characteristic features of periodontal disease. However, targeting DCs and their interactions with other immune cells may provide novel therapeutic approaches for the treatment of periodontal disease. These approaches may include DC-based vaccines or immunotherapies, inhibition of cytokines and chemokines produced by DCs, and targeting the interactions between DCs and other immune cells. Further research is needed to better understand the complex interactions between DCs and other immune cells in the pathogenesis of periodontal disease and to develop effective and safe therapeutic strategies that target DC function. A better understanding of the role of DCs in periodontal disease may lead to the development of new diagnostic tools and treatments for this common and serious oral health condition.