Housing R6/2 Mice with Wild-Type Littermates Increases Lifespan-Reference-Cited by-同舟云学术

Housing R6/2 Mice with Wild-Type Littermates Increases Lifespan

Published:2021-11-09 Issue:4 Volume:10 Page:455-458
ISSN:1879-6397
Container-title:Journal of Huntington's Disease
language:
Short-container-title:JHD

Author:

Story Darren¹²,Gallien John¹³,Al-Gharaibeh Abeer¹³,Sandstrom Michael³²,Rossignol Julien¹³⁴,Dunbar Gary L.¹³²⁵

Affiliation:

1. Field Neurosciences Institute for Restorative Neurology, Central Michigan University, Mount Pleasant, MI, USA

2. Department of Psychology, Central Michigan University, Mount Pleasant, MI, USA

3. Program in Neuroscience, Central Michigan University, Mount Pleasant, MI, USA

4. College of Medicine, Central Michigan University, Mount Pleasant, MI, USA

5. Field Neurosciences Institute, St. Mary’s of Michigan, Saginaw, MI, USA

Abstract

The R6/2 murine model of Huntington’s disease (HD) is extensively used in HD research. The current study replicates and extends previous work assessing the impact of housing R6/2 mice with healthy wild-type (WT) littermates on disease progression. The current study extends the previous finding by including male cohorts and the use of a standard diet and water regimen, as opposed to the enhanced diet used in the previous study. This study found that the inclusion of healthy wild-type (WT) littermates, alone, improved survivabilty in R6/2 mice, but did not have a significant impact on weight loss.

Publisher

IOS Press

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

Reference14 articles.

1. Normal and expanded Huntington’s disease gene alleles produce distinguishable proteins due to translation across the CAG repeat;Persichetti;Mol Med Camb Mass,1995

2. Lack of RAN-mediated toxicity in Huntington’s disease knock-in mice;Yang;Proc Natl Acad Sci U S A,2020

3. Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington’s disease;She;Am J Physiol Endocrinol Metab,2011

4. Environmental enrichment rescues protein deficits in a mouse model of Huntington’s disease, indicating a possible disease mechanism;Spires;J Neurosci,2004

5. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation;Davies;Cell,1997

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice;Experimental Neurology;2024-04