Huntington’s Disease Clinical Trials Corner: April 2022-Reference-Cited by-同舟云学术

Huntington’s Disease Clinical Trials Corner: April 2022

Published:2022-06-03 Issue:2 Volume:11 Page:105-118
ISSN:1879-6397
Container-title:Journal of Huntington's Disease
language:
Short-container-title:JHD

Author:

Estevez-Fraga Carlos¹,Rodrigues Filipe B.¹²³,Tabrizi Sarah J.¹,Wild Edward J.¹

Affiliation:

1. Huntington’s Disease Centre, UCL Queen Square Institute of Neurology, London, UK

2. Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal

3. Instituto de Medicina Molecular, Lisbon, Portugal

Abstract

In this edition of the Huntington’s Disease Clinical Trials Corner we expand on GENERATION HD1, PRECISION-HD1 and PRECISION-HD2, SELECT-HD, and VIBRANT-HD trials, and list all currently registered and ongoing clinical trials in Huntington’s disease.

Publisher

IOS Press

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

Reference21 articles.

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4. Gubser Keller C, Shin Y, Monteys AM, et al. An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion. Nat Commun 2022; 13: 1150.

5. Bhattacharyya A, Trotta CR, Narasimhan J, et al. Small molecule splicing modifiers with systemic HTT-lowering activity. Nat Commun 2021; 12: 7299.

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