Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

Author:

Wilcock Gordon K.1,Gauthier Serge2,Frisoni Giovanni B.3,Jia Jianping4,Hardlund Jiri H.5,Moebius Hans J.6,Bentham Peter7,Kook Karin A.8,Schelter Bjoern O.9,Wischik Damon J.10,Davis Charles S.11,Staff Roger T.12,Vuksanovic Vesna12,Ahearn Trevor12,Bracoud Luc13,Shamsi Kohkan14,Marek Ken15,Seibyl John15,Riedel Gernot16,Storey John M.D.517,Harrington Charles R.516,Wischik Claude M.516

Affiliation:

1. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

2. McGill Centre for Studies in Aging, Alzheimer’s Disease Research Unit, and Douglas Mental Health University Institute, Montreal, QC, Canada

3. University Hospitals and University of Geneva, Geneva, Switzerland

4. Beijing Institute for Brain Disorders Alzheimer’s Disease Centre, Beijing, China

5. TauRx Therapeutics, Aberdeen, UK

6. Moebius-Consult, Baar, Switzerland

7. Birmingham and Solihull Mental Health Foundation Trust, Birmingham, UK

8. Salamandra LLC, Bethesda, MD, USA

9. Institute for Complex Systems and Mathematical Biology, University of Aberdeen, Aberdeen, UK

10. Computer Laboratory, University of Cambridge, Cambridge, UK

11. CSD Biostatistics, Tucson, AZ, USA

12. Aberdeen Biomedical Imaging Centre, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK

13. BioClinica, Lyon, France

14. RadMD, New York, NY, USA

15. MNI Imaging, New Haven, CT, USA

16. School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK

17. Department of Chemistry, University of Aberdeen, Aberdeen, UK

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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