Normal Pressure Hydrocephalus in Down Syndrome: The Report of Two Cases-Reference-Cited by-同舟云学术

Normal Pressure Hydrocephalus in Down Syndrome: The Report of Two Cases

Published:2020-09-29 Issue:3 Volume:77 Page:979-984
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Marano Massimo¹,Pompucci Angelo²,Motolese Francesco¹,Rossi Mariagrazia¹,Coletta Ernesto³,Di Lazzaro Vincenzo¹,Fasano Alfonso⁴⁵⁶⁷,Petrella Gianpaolo²

Affiliation:

1. Neurology, Neurophysiology and Neurobiology unit, Department of Medicine, University Campus Bio-Medico of Rome, Italy

2. Department of Neurosurgery, S. Maria Goretti Hospital, Latina, Italy

3. Neurology, ASL di Aprilia, Italy

4. Edmond J. Safra Program in Parkinson’s Disease and the Morton and Gloria Shulman Movement Disorders Centre and the, Toronto Western Hospital, UHN, Toronto, Ontario, Canada

5. Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada

6. Krembil Brain Institute, Toronto, Ontario, Canada

7. CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada

Abstract

Down syndrome (DS) is the most common cause of intellectual disability in infants and has a well-known relationship with the Alzheimer’s disease. The association between DS and the other pathologies of senescence, such as normal pressure hydrocephalus (NPH), has been poorly investigated. This series included two DS patients with NPH. In both cases, NPH symptoms were initially misdiagnosed as DS associated senescence. Patients were treated with ventricular-peritoneal shunt, showing a sustained improvement (1 and 4 years of follow-up). To our knowledge, this is the first description of the occurrence of NPH in adult patients with DS and surgical outcomes.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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4. Reappraisal of Pediatric Normal-Pressure Hydrocephalus;Journal of Clinical Medicine;2021-05-09