Treatment with anticoagulants in cerebral events (TRACE)

Author:

Woessner Ralph,Grauer Markus,Bianchi Oliver,Mueller Martin,Moersdorf Stefan,Berlit Peter,Goertler Michael,Grotemeyer Karl-Heinz,Sliwka Ulrich,Stoll Martin,Treib Johannes

Abstract

Summary90 patients with acute stroke and a concomitant cardiac embolism source or a symptomatic high-grade stenosis of an extraor intracranial vessel received in a mulitcenter, randomized, controlled study either Enoxaparin 1 mg/kg BW s.c. b.i.d. or i.v. heparin aPTT-adjusted daily for 8 +/−2 days as secondary prophylaxis. There were no significant differences between the two groups regarding cerebral and systemic embolic events, bleeding complications, length of hospital stay, number of diagnostic and therapeutic measures and outcome after three months. This suggests that Enoxaparin, which is easier to administer and monitor, is a safe drug in patients with acute cerebral events.

Funder

Aventis Pharma (formerly Rhone-Poulenc Rorer)

Publisher

Georg Thieme Verlag KG

Subject

Hematology

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