Endocytic receptor for pro-coagulant factor VIII: Relevance to inhibitor formation-Reference-Cited by-同舟云学术

Endocytic receptor for pro-coagulant factor VIII: Relevance to inhibitor formation

Published:2010 Issue:12 Volume:104 Page:1093-1098
ISSN:0340-6245
Container-title:Thrombosis and Haemostasis
language:en
Short-container-title:Thromb Haemost

Author:

Navarrete Ana-Maria,Dasgupta Suryasarathi,Teyssandier Maud,Repessé Yohann,Delignat Sandrine,André Sébastien,Bayry Jagadeesh,Kaveri Srinivas V.,Lacroix-Desmazes Sébastien

Abstract

SummaryThe immunogenicity of therapeutic factor VIII (FVIII) in patients with haemophilia A remains a critical issue in patient management. This review describes the immunological processes involved in the activation of the immune system against FVIII, with a particular focus on the role of endocytic receptors for the recognition of FVIII by antigen-presenting cells.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH10-05-0294.pdf

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1. Biochemical characterization and immunogenicity of Neureight, a recombinant full-length factor VIII produced by fed-batch process in disposable bioreactors;Cellular Immunology;2018-09

2. Inhibitor Formation in Congenital Hemophilia A: an Immunological Perspective;Seminars in Thrombosis and Hemostasis;2018-06-04

3. Progress of Hemophilia A Therapeutics in Korea;Clinical Pediatric Hematology-Oncology;2018-04-30

4. The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells;Haematologica;2016-10-06

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